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Article

Efficient reconstruction of cell lineage trees for cell ancestry and cancer.

Nucleic acids research - 9 Jun 2023

Jang Yeongjun, Fasching Liana, Bae Taejeong, Tomasini Livia, Schreiner Jeremy, Szekely Anna, Fernandez Thomas V, Leckman James F, Vaccarino Flora M, Abyzov Alexej

Abstract excerpt

Mosaic mutations can be used to track cell ancestries and reconstruct high-resolution lineage trees during cancer progression and during development, starting from the first cell divisions of the zygote. However, this approach requires sampling and analyzing the genomes of multiple cells, which can be redundant in lineage representation, limiting the scalability of the approach. We describe a strategy for cost-...

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PMID: 37026484
DOI: 10.1093/nar/gkad254
PMCID: PMC10250207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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