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Analysis of clinical Candida parapsilosis isolates reveals copy number variation in key fluconazole resistance genes

7 May 2024

Abstract excerpt

ABSTRACT We used whole-genome sequencing to analyze a collection of 35 fluconazole-resistant and 7 susceptible Candida parapsilosis isolates together with coverage analysis and GWAS techniques to identify new mechanisms of fluconazole resistance. Phylogenetic analysis shows that although the collection is diverse, two persistent clinical lineages were identified. We identified copy number variation (CNV) of two...

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PMID: 38712935
DOI: 10.1128/aac.01619-23

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