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Article

PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.

Molecular biology reports - 1 Dec 2023

Hong Yiyi, Jiang Li, Tang Fen, Zhang Mingyuan, Cui Ling, Zhong Haibin, Xu Fan, Li Min, Chen Changzheng, Chen Lifei

Abstract excerpt

BACKGROUND: Recent reports suggest that peroxisome proliferator-activated receptor-γ (PPAR-γ) could promote microglial M2 polarization to inhibit inflammation. However, the specific molecular mechanisms that trigger PPAR-γ's anti-inflammatory ability in microglia are yet to be expounded. Thus, in this study, we aimed to explore the molecular mechanisms behind the anti-inflammatory effects of PPAR-γ in...

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PMID: 37971567
DOI: 10.1007/s11033-023-08815-5

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