Article

β3-adrenergic blockade targets fatty acid oxidation to induce ferroptotic vulnerability in pediatric T-ALL

2026-04-22

Abstract excerpt

<title>Abstract</title> <p>Pediatric T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of childhood ALL and is associated with a high risk of relapse, with ~ 25% of patients failing conventional therapy. Resistance is driven by pro-survival signaling, impaired apoptosis, and metabolic adaptations that sustain leukemic proliferation under stress. Herein, we investigate the role of β3-adren...

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Literature Corpus work: bfd56716-55fc-5691-97ce-1cde8f83f5f5
DOI: 10.21203/rs.3.rs-9392453/v1

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