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The Drivers, Mechanisms, and Consequences of Genome Instability in HPV-Driven Cancers

23 Sept 2022

Abstract excerpt

Human papillomavirus (HPV) is the causative driver of cervical cancer and a contributing risk factor of head and neck cancer and several anogenital cancers. HPV's ability to induce genome instability contributes to its oncogenicity. HPV genes can induce genome instability in several ways, including modulating the cell cycle to favour proliferation, interacting with DNA damage repair pathways to bring...

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PMID: 36230545
DOI: 10.3390/cancers14194623

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