Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue

31 May 2021

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomerase-independent, recombination-based telomere maintenance mechanism that allows cancer cells to acquire unlimited proliferative capacity. The C-circle assay (CCA) has emerged as the gold standard for quantitative measurement of ALT activity. Here, we present a modified CCA protocol to examine ALT activity in formalin-fixed paraffin-embedded specimens. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to CRISPR and Genetic Engineering
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34136834
DOI: 10.1016/j.xpro.2021.100569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissuePMID 34136834Read ↗

Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cellsSemantic proximity Read ↗

Detection of alternative lengthening of telomeres by telomere quantitative PCRSemantic proximity Read ↗

Telomere sequence content can be used to determine ALT activity in tumours.Semantic proximity Read ↗

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancersSemantic proximity Read ↗

Alternative Lengthening of Telomeres is not synonymous with mutations in ATRX/DAXXSemantic proximity Read ↗

Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanismSemantic proximity Read ↗

Prevalence of Alternative Lengthening of Telomeres (ALT) in Pediatric Sarcomas Determined by the Telomeric DNA C-circle AssaySemantic proximity Read ↗

Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)Semantic proximity Read ↗

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancersSemantic proximity Read ↗

Prevalence of alternative lengthening of telomeres in pediatric sarcomas determined by the telomeric DNA C-circle assaySemantic proximity Read ↗

Single-molecule real-time detection of telomerase extension activitySemantic proximity Read ↗

Analysis of alternative lengthening of telomere markers in BRCA1 defective cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.