Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.

Cancer research - 15 Feb 2007

Compton Sarah A, Choi Jun-Hyuk, Cesare Anthony J, Ozgür Sezgin, Griffith Jack D

Abstract excerpt

The maintenance of telomere length is essential for the indefinite proliferation of cancer cells. This is most often achieved by the activation of telomerase; however, a substantial number of cancers lack detectable telomerase activity and are classified as using an alternative lengthening of telomeres (ALT) pathway. We showed recently that ALT cells have a high level of extrachromosomal telomeric circles (t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Cell Growth Processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to DNA-Binding Proteins

Share to Nuclear Proteins

Share to RNA, Small Interfering

Share to Telomerase

Share to Telomere

Source

Identifiers

PMID: 17308089
DOI: 10.1158/0008-5472.CAN-06-3672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.PMID 17308089Read ↗

Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanismsSemantic proximity Read ↗

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres PathwaySemantic proximity Read ↗

Alternative lengthening of telomeres: mechanism and the pathogenesis of cancerSemantic proximity Read ↗

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cellsSemantic proximity Read ↗

Hyperextended telomeres promote formation of C-circle DNA in telomerase positive human cellsSemantic proximity Read ↗

DNA Damage Induces Alternative Lengthening of Telomeres (ALT)–Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNASemantic proximity Read ↗

The first molecular details of ALT in human tumor cellsSemantic proximity Read ↗

Alternative lengthening of telomeres in mammalian cells.Semantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancersSemantic proximity Read ↗

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancersSemantic proximity Read ↗

Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.