Article
Progressive metastatic infantile fibrosarcoma with multiple acquired mutations.
Cold Spring Harbor molecular case studies - 1 Apr 2023
Furtado Larissa V, Kacar Marija, Mostafavi Roya, Shi Zonggao, Ruiz Robert, Koo Selene C, Santiago Teresa, Segers Blair, Krasin Matthew J, Abramson Zachary R, Shulkin Barry, Talbot Lindsay J, Pappo Alberto, Gartrell Jessica
Abstract excerpt
Infantile fibrosarcoma is the most common soft-tissue sarcoma in children under the age of 1 yr and is defined molecularly by NTRK fusion proteins. This tumor is known to be locally invasive; however, although rare, metastases can occur. The NTRK fusion acts as a driver for tumor formation, which can be targeted by first- and second-generation TRK inhibitors. Although NTRK gatekeeper mutations have been...
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