Infantile Fibrosarcoma With <i>NTRK3–ETV6</i> Fusion Successfully Treated With the Tropomyosin‐Related Kinase Inhibitor LOXO‐101

Abstract excerpt

Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from an ETS variant...

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