Article

TRK expressions and NTRK rearrangements in Pediatric Tumors

2025-09-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Neurotrophic tyrosine receptor kinase (NTRK) genes that include NTRK1, NTRK2, NTRK3 and express TRKA, TRKB, TRKC proteins, respectively, are oncogenic drivers in distinct types of cancer. NTRK fusions with other genes result in constitutively active TRK protein expressions that enhance tumor progression. NTRK fusions were found in more than twenty-five types of...

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Literature Corpus work: 53c4b867-c8b3-5c5c-bc0e-4ea1811aab4c
DOI: 10.21203/rs.3.rs-7527708/v1

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