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Article

Clinical characteristics and prognostic significance of DNA methylation regulatory gene mutations in acute myeloid leukemia.

Clinical epigenetics - 29 Mar 2023

Xu Xiaoyan, Wang Hong, Han Haohao, Yao Yifang, Li Xueqian, Qi Jiaqian, Cai Chengsen, Zhou Meng, Tang Yaqiong, Pan Tingting, Zhang Ziyan, Yang Jingyi, Wu Depei, Han Yue

Abstract excerpt

BACKGROUND: DNA methylation is a form of epigenetic modification that regulates gene expression. However, there are limited data on the comprehensive analysis of DNA methylation regulated gene mutations (DMRGM) in acute myeloid leukemia (AML) mainly referring to DNA methyltransferase 3α (DNMT3A), isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), and Tet methylcytidine dioxygenase 2 (TET2)....

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Identifiers

PMID: 36991512
DOI: 10.1186/s13148-023-01474-0
PMCID: PMC10061765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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