Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations.

doi:10.3324/haematol.2016.143073

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Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations.

Haematologica - 1 Sept 2016

Ryotokuji Takeshi, Yamaguchi Hiroki, Ueki Toshimitsu, Usuki Kensuke, Kurosawa Saiko, Kobayashi Yutaka, Kawata Eri, Tajika Kenji, Gomi Seiji, Kanda Junya, Kobayashi Anna, Omori Ikuko, Marumo Atsushi, Fujiwara Yusuke, Yui Shunsuke, Terada Kazuki, Fukunaga Keiko, Hirakawa Tsuneaki, Arai Kunihito, Kitano Tomoaki, Kosaka Fumiko, Tamai Hayato, Nakayama Kazutaka, Wakita Satoshi, Fukuda Takahiro, Inokuchi Koiti

Abstract excerpt

In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations - mutations of the genes that regulate gene expression through DNA methylation - is high in acute myeloid leukemia. The objective of the present study was to elucidate the clinical characteristics and prognosis of acute myeloid leukemia with associated DNA-methylation regulatory gene mutation. We studied 308...

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PMID: 27247325
DOI: 10.3324/haematol.2016.143073
PMCID: PMC5060024

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FLT3

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