Article
Mutations in Classical Signaling Pathways and Their Functional Impact in Microsatellite Instability High Colorectal Cancer.
Genetic testing and molecular biomarkers - 1 Mar 2023
Shi Shanshan, Gong Yuxi, Li Xiao, Ding Ying, Song Guoxin, Liu Haiyan, Zhang Zhihong
Abstract excerpt
Aims: Colorectal carcinomas with microsatellite instability high (MSI-H) are a distinctive group among colorectal cancers (CRCs). This study investigated the mutations of genes in the common signaling pathways and their potential clinical implications in MSI-H CRC. Materials and Methods: Twenty-five MSI-H tumors were selected from 384 primary CRCs, and the related clinical and pathological information were also...
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