Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency.

The Journal of pathology - 1 Dec 2012

Tian Sun, Roepman Paul, Popovici Vlad, Michaut Magali, Majewski Ian, Salazar Ramon, Santos Cristina, Rosenberg Robert, Nitsche Ulrich, Mesker Wilma E, Bruin Sjoerd, Tejpar Sabine, Delorenzi Mauro, Bernards Rene, Simon Iris

Abstract excerpt

Microsatellite instability (MSI) occurs in 10-20% of colorectal tumours and is associated with good prognosis. Here we describe the development and validation of a genomic signature that identifies colorectal cancer patients with MSI caused by DNA mismatch repair deficiency with high accuracy. Microsatellite status for 276 stage II and III colorectal tumours has been determined. Full-genome expression data was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Testing

Share to Genomics

Share to Microsatellite Instability

Share to Mutation Rate

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22926706
DOI: 10.1002/path.4092
PMCID: PMC3532622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency.PMID 22926706Read ↗

Gene expression signatures for colorectal cancer microsatellite status and HNPCCSemantic proximity Read ↗

A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.Semantic proximity Read ↗

Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach.Semantic proximity Read ↗

Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part I-Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications.Semantic proximity Read ↗

The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing.Semantic proximity Read ↗

Molecular pathological classification of colorectal cancer.Semantic proximity Read ↗

Gene mutation profiling in microsatellite instability colorectal cancer and its association with the efficacy of immunotherapy: A retrospective study.Semantic proximity Read ↗

Gene expression differences among different MSI statuses in colorectal cancer.Semantic proximity Read ↗

Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in CancersSemantic proximity Read ↗

DNA Mismatch Repair Deficiency Detection in Colorectal Cancer by a New Microsatellite Instability Analysis System.Semantic proximity Read ↗

Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.Semantic proximity Read ↗

Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability StatusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.