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STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?

21 Jan 2021

Abstract excerpt

The anti-viral pattern recognition receptor STING and its partnering cytosolic DNA sensor cGAS have been increasingly recognized to respond to self DNA in multiple pathologic settings including cancer and autoimmune disease. Endogenous DNA sources that trigger STING include damaged nuclear DNA in micronuclei and mitochondrial DNA (mtDNA). STING resides in the endoplasmic reticulum (ER), and particularly in the...

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PMID: 33552072
DOI: 10.3389/fimmu.2020.611347

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