Article
Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling.
International journal of molecular sciences - 15 Mar 2023
Turi Marcello, Anilkumar Sithara Anjana, Hofmanová Lucie, Žihala David, Radhakrishnan Dhwani, Vdovin Alexander, Knápková Sofija, Ševčíková Tereza, Chyra Zuzana, Jelínek Tomáš, Šimíček Michal, Gullà Annamaria, Anderson Kenneth Carl, Hájek Roman, Hrdinka Matouš
Abstract excerpt
During innate immune responses, myeloid differentiation primary response 88 (MyD88) functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors (TLR) and the interleukin-1 receptor (IL-1R) family and translates them into specific cellular outcomes. In B cells, somatic mutations in MyD88 trigger oncogenic NF-κB signaling independent of receptor stimulation, which leads to the...
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