Article
Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma.
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2017
Shimada Kazuyuki
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype of non-Hodgkin lymphoma, accounting for 30%-40% of all types of malignant lymphoma. Importantly, two distinct molecular subtypes, germinal center B-cell (GCB) type and activated B-cell (ABC) type, arising from B lymphocyte differentiation based on the gene expression profiling opened doors to uncover molecular pathogenesis in DLBCL. Since...
Topics
- Disease Progression
- Humans
- Lymphoma, Large B-Cell, Diffuse
- Molecular Targeted Therapy
- Mutation
- Receptors, Antigen, B-Cell
- Signal Transduction