Oncogenically active MYD88 mutations in human lymphoma.

doi:10.1038/nature09671

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Article

Oncogenically active MYD88 mutations in human lymphoma.

Nature - 3 Feb 2011

Ngo Vu N, Young Ryan M, Schmitz Roland, Jhavar Sameer, Xiao Wenming, Lim Kian-Huat, Kohlhammer Holger, Xu Weihong, Yang Yandan, Zhao Hong, Shaffer Arthur L, Romesser Paul, Wright George, Powell John, Rosenwald Andreas, Muller-Hermelink Hans Konrad, Ott German, Gascoyne Randy D, Connors Joseph M, Rimsza Lisa M, Campo Elias, Jaffe Elaine S, Delabie Jan, Smeland Erlend B, Fisher Richard I, Braziel Rita M, Tubbs Raymond R, Cook J R, Weisenburger Denny D, Chan Wing C, Staudt Louis M

Abstract excerpt

The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this malignancy despite recent advances in therapy. Constitutive nuclear factor (NF)-κB and JAK kinase signalling promotes malignant cell survival in these lymphomas, but the genetic basis for this signalling is incompletely understood. Here we describe the dependence of ABC DLBCLs on MYD88, an...

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Identifiers

PMID: 21179087
DOI: 10.1038/nature09671
PMCID: PMC5024568

Genes

MYD88
IRAK4
IRAK1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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