Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P-Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases.

doi:10.1158/1078-0432.CCR-16-1922

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Article

Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P-Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2017

Dubois Sydney, Viailly Pierre-Julien, Bohers Elodie, Bertrand Philippe, Ruminy Philippe, Marchand Vinciane, Maingonnat Catherine, Mareschal Sylvain, Picquenot Jean-Michel, Penther Dominique, Jais Jean-Philippe, Tesson Bruno, Peyrouze Pauline, Figeac Martin, Desmots Fabienne, Fest Thierry, Haioun Corinne, Lamy Thierry, Copie-Bergman Christiane, Fabiani Bettina, Delarue Richard, Peyrade Frédéric, André Marc, Ketterer Nicolas, Leroy Karen, Salles Gilles, Molina Thierry J, Tilly Hervé, Jardin Fabrice

Abstract excerpt

Purpose:MYD88 mutations, notably the recurrent gain-of-function L265P variant, are a distinguishing feature of activated B-cell like (ABC) diffuse large B-cell lymphoma (DLBCL), leading to constitutive NFκB pathway activation. The aim of this study was to examine the distinct genomic profiles of MYD88-mutant DLBCL, notably according to the presence of the L265P or other non-L265P MYD88 variants.Experimental...

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PMID: 27923841
DOI: 10.1158/1078-0432.CCR-16-1922

Genes

MYD88
BTK

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