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Article

Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.

Journal of virology - 1 Jul 2011

Hansman Grant S, Biertümpfel Christian, Georgiev Ivelin, McLellan Jason S, Chen Lei, Zhou Tongqing, Katayama Kazuhiko, Kwong Peter D

Abstract excerpt

Noroviruses are the dominant cause of outbreaks of gastroenteritis worldwide, and interactions with human histo-blood group antigens (HBGAs) are thought to play a critical role in their entry mechanism. Structures of noroviruses from genogroups GI and GII in complex with HBGAs, however, reveal different modes of interaction. To gain insight into norovirus recognition of HBGAs, we determined crystal structures of...

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Identifiers

PMID: 21525337
DOI: 10.1128/JVI.00246-11
PMCID: PMC3126497

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Source receipt: pubmed, retrieved 7 Sept 2026.

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