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Article

Case report: Targeting the PD-1 receptor and genetic mutations validated in primary histiocytic sarcoma with hemophagocytic lymphohistiocytosis.

Frontiers in immunology - 1 Jan 2023

Zhao Yan, Deng Yating, Jiang Yi, Zheng Wenli, Tan Yanlin, Yang Zhiwu, Wang Zhihua, Xu Feng, Cheng Zhao, Yuan Lingli, Peng Hongling

Abstract excerpt

Histiocytic sarcoma (HS) is a rare hematological malignancy with limited treatment options, and it is also prone to complications such as hemophagocytic lymphohistiocytosis (HLH) in the later stages of the disease, leading to difficulties in treatment and poor prognosis. It highlights the importance of developing novel therapeutic agents. Herein, we present a case of a 45-year-old male patient who was diagnosed...

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Identifiers

PMID: 36969238
DOI: 10.3389/fimmu.2023.1127599
PMCID: PMC10030599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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