Article

Management of Refractory Malignancy-Associated Hemophagocytic Lymphohistiocytosis in Pediatric Patients: A Case Series of Novel Therapeutics and Treatment Challenges

2025-01-04

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal syndrome of immune dysregulation that has primary and secondary forms. HLH is classified based on underlying triggers of malignancy, infections, and/or autoimmune processes. Primary-HLH has a genetic etiology related to defects in cytotoxic T and NK cells. The established standard of care is dexamethasone and etoposide but no guidelines exist for refr...

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Literature Corpus work: dd7d51ac-0d00-5943-a86b-d3a27fde8215
DOI: 10.22541/au.173599410.06496449/v1

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