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Article

MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression.

Frontiers in immunology - 1 Jan 2023

Schrörs Barbara, Hos Brett J, Yildiz Ikra G, Löwer Martin, Lang Franziska, Holtsträter Christoph, Becker Julia, Vormehr Mathias, Sahin Ugur, Ossendorp Ferry, Diken Mustafa

Abstract excerpt

Introduction: The cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and endogenous CD8+ T cell responses against neoantigens have been reported. Methods: Here, we re-sequenced exomes and transcriptomes of MC38 cells from two different sources, namely Kerafast (originating from NCI/NIH, MC38-K) and the Leiden...

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Identifiers

PMID: 36969213
DOI: 10.3389/fimmu.2023.1102282
PMCID: PMC10030996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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