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Article

Anti-oncogenic and immunological functions of ATP23 in CMS4 colon adenocarcinoma based on a machine learning computational framework.

PeerJ - 1 Jan 2026

Yin Yafei, Zhang Huimin, Li Shuai, Gu Ruru, Wang Jian, Zhang Zhen, Sun Juntao

Abstract excerpt

Background: Consensus Molecular Subtype (CMS) 4 and BRAF mutations are poor prognostic indicators for colon adenocarcinoma (COAD). Although the prevalence of BRAF-mutated COAD is higher in the CMS1 subtype, we have identified certain cases of CMS4 subtypes in patients with BRAF mutations. However, there is currently a lack of research exploring whether this particular type of COAD exhibits a worse prognosis and...

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Share to Adenocarcinoma
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Colonic Neoplasms

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Share to Gene Expression Regulation, Neoplastic

Share to Mitochondrial Proton-Translocating ATPases

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 41736753
DOI: 10.7717/peerj.20838
PMCID: PMC12927601

Genes

ATP23
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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