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Article

Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction.

Cancer research communications - 1 Feb 2023

Florian David C, Bennett Natalie E, Odziomek Mateusz, Baljon Jessalyn J, Wehbe Mohamed, Merkel Alyssa R, Fischer Melissa A, Savona Michael R, Rhoades Julie A, Guelcher Scott A, Wilson John T

Abstract excerpt

When breast cancer metastasizes to bone, treatment options are limited. Failure to treat bone metastases is thought to be due to therapy-resistant features of the bone marrow microenvironment. Using a murine model of bone metastatic mammary carcinoma, we demonstrate that systemic delivery of polymer nanoparticles loaded with cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) inhibited...

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Identifiers

PMID: 36968140
DOI: 10.1158/2767-9764.CRC-22-0180
PMCID: PMC10035525

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