Estimating mutation rates in a Markov branching process using approximate Bayesian computation.

Abstract excerpt

Estimating microbial mutation rates is an essential task in evolutionary biology, with wide range applications in related fields such as virology, epidemiology, clinic and public health, and antibiotic research. Significant progress has been made on this research since 1943 when Luria-Delbrück fluctuation analysis was first introduced. However, existing estimators of mutation rates are heavily reliant on model...

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