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Article

Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos.

Scientific reports - 6 Mar 2018

Lavagi Ilaria, Krebs Stefan, Simmet Kilian, Beck Andrea, Zakhartchenko Valeri, Wolf Eckhard, Blum Helmut

Abstract excerpt

Embryonic development is initially controlled by maternal RNAs and proteins stored in the oocyte, until gene products gradually generated by the embryo itself take over. Major embryonic genome activation (EGA) in bovine embryos occurs at the eight- to 16-cell stage. Morphological observations, such as size of blastomeres and distribution of microvilli, suggested heterogeneity among individual cells already at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29511234
DOI: 10.1038/s41598-018-22248-2
PMCID: PMC5840315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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