Decarboxylation and Protonation Enigma in the H85Q Mutant of Cytochrome P450OleT.

doi:10.1021/acs.jpcb.3c00143

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Article

Decarboxylation and Protonation Enigma in the H85Q Mutant of Cytochrome P450OleT.

The journal of physical chemistry. B - 6 Apr 2023

Yadav Shalini, Shaik Sason, Dubey Kshatresh Dutta

Abstract excerpt

Cytochrome P450OleT (CYP450OleT), a member of CYP450 peroxygenases, catalyzes unusual decarboxylation activity. Unlike other members of the peroxygenases family, CYP450OleT possesses a histidine at the 85th position, which was supposed to be the root cause of the decarboxylation activity in CYP450OleT. This work addresses the His85 → Gln mutant paradox, where mutation of His → Gln still shows efficient...

Topics

Histidine
Decarboxylation
Mutation
Cytochrome P-450 Enzyme System

Source

Open in PubMed

Identifiers

PMID: 36959730
DOI: 10.1021/acs.jpcb.3c00143

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