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Article

E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2.

Biophysical journal - 4 Aug 2020

Matsumoto Shigeyuki, Araki Mitsugu, Isaka Yuta, Ono Fumie, Hirohashi Kenshiro, Ohashi Shinya, Muto Manabu, Okuno Yasushi

Abstract excerpt

Mitochondrial aldehyde dehydrogenase 2 (ALDH2), which is a homotetramer assembled by two equivalent dimers, is an important enzyme that metabolizes ethanol-derived acetaldehyde to acetate in a coenzyme-dependent manner. The highly reactive acetaldehyde exhibits a toxic effect, indicating that the proper functioning of ALDH2 is essential to counteract aldehyde-associated diseases. It is known that the catalytic...

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Identifiers

PMID: 32681823
DOI: 10.1016/j.bpj.2020.07.002
PMCID: PMC7399495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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