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Article

The intramembrane COOH-terminal domain of PRRT2 regulates voltage-dependent Na+ channels.

The Journal of biological chemistry - 1 May 2023

Franchi Francesca, Marte Antonella, Corradi Beatrice, Sterlini Bruno, Alberini Giulio, Romei Alessandra, De Fusco Antonio, Vogel Alexander, Maragliano Luca, Baldelli Pietro, Corradi Anna, Valente Pierluigi, Benfenati Fabio

Abstract excerpt

Proline-rich transmembrane protein 2 (PRRT2) is the single causative gene for pleiotropic paroxysmal syndromes, including epilepsy, kinesigenic dyskinesia, episodic ataxia, and migraine. PRRT2 is a neuron-specific type-2 membrane protein with a COOH-terminal intramembrane domain and a long proline-rich NH2-terminal cytoplasmic region. A large array of experimental data indicates that PRRT2 is a neuron stability...

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Identifiers

PMID: 36958475
DOI: 10.1016/j.jbc.2023.104632
PMCID: PMC10164911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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