Article

An extended structure of the intracellular domain of the Torpedo nicotinic acetylcholine receptor and its proposed interactions with rapsyn

2025-12-04

Abstract excerpt

To gain insight into the interactions between rapsyn and the nAChR that induce clustering at the post-synaptic membrane, we refined a cryo-EM dataset using an intracellular domain focused strategy to obtain a 3.0 Å map with the most extensive density yet for the intracellular domain of the Torpedo nAChR. The improved map allowed us to extend the structure beyond the MX α-helix and prior to the MA α-helix of the i...

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Literature Corpus work: 57f499a8-075f-54a5-b7bd-569f0620be5c
DOI: 10.64898/2025.12.03.692134

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