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Article

Full-length isoform transcriptome of the developing human brain provides further insights into autism.

Cell reports - 31 Aug 2021

Chau Kevin K, Zhang Pan, Urresti Jorge, Amar Megha, Pramod Akula Bala, Chen Jiaye, Thomas Amy, Corominas Roser, Lin Guan Ning, Iakoucheva Lilia M

Abstract excerpt

Alternative splicing plays an important role in brain development, but its global contribution to human neurodevelopmental diseases (NDDs) requires further investigation. Here we examine the relationships between splicing isoform expression in the brain and de novo loss-of-function mutations from individuals with NDDs. We analyze the full-length isoform transcriptome of the developing human brain and observe...

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Identifiers

PMID: 34469739
DOI: 10.1016/j.celrep.2021.109631
PMCID: PMC8437376

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