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Article

Multiple functional domains of the yeast l,3-beta-glucan synthase subunit Fks1p revealed by quantitative phenotypic analysis of temperature-sensitive mutants.

Genetics - 1 Apr 2010

Okada Hiroki, Abe Mitsuhiro, Asakawa-Minemura Masayo, Hirata Aiko, Qadota Hiroshi, Morishita Kana, Ohnuki Shinsuke, Nogami Satoru, Ohya Yoshikazu

Abstract excerpt

The main filamentous structural component of the cell wall of the yeast Saccharomyces cerevisiae is 1,3-beta-glucan, which is synthesized by a plasma membrane-localized enzyme called 1,3-beta-glucan synthase (GS). Here we analyzed the quantitative cell morphology and biochemical properties of 10 different temperature-sensitive mutants of FKS1, a putative catalytic subunit of GS. To untangle their pleiotropic...

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PMID: 20124029
DOI: 10.1534/genetics.109.109892
PMCID: PMC2865904

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