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Article

Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism.

The Journal of molecular diagnostics : JMD - 1 Nov 2024

Sterner Rosalie M, Hall Patricia L, Matern Dietrich, Black John L, Moyer Ann M

Abstract excerpt

Thiopurine 6-mercaptopurine (6-MP) is metabolized by thiopurine methyl transferase (TPMT). TPMT genetic variation results in some individuals having reduced or absent TPMT enzyme activity. If these individuals take a full thiopurine dose, life-threatening adverse events can occur. Testing identifies patients with reduced or absent TPMT activity and is recommended before initiation of therapy. The TPMT∗8 allele,...

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Identifiers

PMID: 39182670
DOI: 10.1016/j.jmoldx.2024.07.005

Genes

TPMT

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