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Regulation of USP25 by SP1 Associates with Amyloidogenesis

14 Mar 2023

Abstract excerpt

BACKGROUND: Trisomy 21, an extra copy of human chromosome 21 (HSA21), causes most Down's syndrome (DS) cases. Individuals with DS inevitably develop Alzheimer's disease (AD) neuropathological phenotypes after middle age including amyloid plaques and tau neurofibrillary tangles. Ubiquitin Specific Peptidase 25 (USP25), encoding by USP25 gene located on HSA21, is a deubiquitinating enzyme, which plays an important...

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PMID: 36938736
DOI: 10.3233/jad-221184

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