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Article

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

The Journal of biological chemistry - 11 Aug 2017

Jiang Lu, Xiong Jiannan, Zhan Junsi, Yuan Fengjie, Tang Ming, Zhang Chaohua, Cao Ziyang, Chen Yongcan, Lu Xiaopeng, Li Yinglu, Wang Hui, Wang Lina, Wang Jiadong, Zhu Wei-Guo, Wang Haiying

Abstract excerpt

Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage. Interestingly, SIRT7 is linked to the control of glycolysis, suggesting a role in glucose metabolism. Given the important roles of SIRT7, it is critical to clarify how SIRT7 activity is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28655758
DOI: 10.1074/jbc.M117.780130
PMCID: PMC5555190

Genes

SIRT7
USP7
ELK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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