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Article

USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.

Molecular and cellular neurosciences - 1 Jun 2002

Hong Sunghoi, Kim Sung-Jo, Ka Sojeong, Choi Inho, Kang Seongman

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration. SCA1 has been known to associate with elongated polyglutamine tract in ataxin-1, the SCA1 gene product. Using the yeast two-hybrid system, we have found that USP7, a ubiquitin-specific protease, binds to ataxin-1. Further experiments with deletion mutants indicated...

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Share to Ataxin-1
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Share to Inclusion Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Purkinje Cells

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Share to Trinucleotide Repeat Expansion

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Source

Identifiers

PMID: 12093161
DOI: 10.1006/mcne.2002.1103

Genes

USP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.PMID 12093161Read ↗

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