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Article

Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2022

Wang Chong, Zhang Yuan, Zhao Dongdong, Huo Yuanhui, Xie Jieru, Zhang Xian, Luo Hong, Xu Huaxi, Zhang Yun-Wu

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia with no effective treatment options. A complete elucidation of its underlying molecular mechanisms, including the transcription regulation of genes critically involved in AD, may shed light on new therapeutic development. RPS23RG1 is a newly identified AD-associated gene, whose expression is decreased in AD and restoration can attenuate AD-like...

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Identifiers

PMID: 35821069
DOI: 10.1038/s41386-022-01373-7
PMCID: PMC9556769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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