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Article

Regulation of global gene expression and cell proliferation by APP

3 Mar 2016

Abstract excerpt

Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor protein (APP) is increased in both DS and AD patients. To reveal the function of APP and elucidate...

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PMID: 26936520
DOI: 10.1038/srep22460

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