Article
Unraveling the genetic landscape of susceptibility to multiple primary cancers.
HGG advances - 10 Apr 2025
Middha Pooja, Kachuri Linda, Nierenberg Jovia L, Graff Rebecca E, Cavazos Taylor B, Hoffmann Thomas J, Zhang Jie, Alexeeff Stacey, Habel Laurel, Corley Douglas A, Van Den Eeden Stephen, Kushi Lawrence H, Ziv Elad, Sakoda Lori C, Witte John S
Abstract excerpt
With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought to explore the role of common genetic variation in susceptibility to multiple primary tumors. We conducted a cross-ancestry genome-wide association study (GWAS) and...
Read the complete abstract on PubMedTopics
- Humans
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Neoplasms, Multiple Primary
- Female