Article
The architecture of parent-of-origin effects in mice.
Cell - 16 Jan 2014
Mott Richard, Yuan Wei, Kaisaki Pamela, Gan Xiangchao, Cleak James, Edwards Andrew, Baud Amelie, Flint Jonathan
Abstract excerpt
The number of imprinted genes in the mammalian genome is predicted to be small, yet we show here, in a survey of 97 traits measured in outbred mice, that most phenotypes display parent-of-origin effects that are partially confounded with family structure. To address this contradiction, using reciprocal F1 crosses, we investigated the effects of knocking out two nonimprinted candidate genes, Man1a2 and H2-ab1,...
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