Article
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations.
Epigenetics - 1 Dec 2023
Chen Junyu, Gatev Evan, Everson Todd, Conneely Karen N, Koen Nastassja, Epstein Michael P, Kobor Michael S, Zar Heather J, Stein Dan J, Hüls Anke
Abstract excerpt
Recent efforts have focused on developing methylation risk scores (MRS), a weighted sum of the individual's DNA methylation (DNAm) values of pre-selected CpG sites. Most of the current MRS approaches that utilize Epigenome-wide association studies (EWAS) summary statistics only include genome-wide significant CpG sites and do not consider co-methylation. New methods that relax the p-value threshold to include...
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