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Article

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.

Nature communications - 11 Oct 2016

Kessler Michael D, Yerges-Armstrong Laura, Taub Margaret A, Shetty Amol C, Maloney Kristin, Jeng Linda Jo Bone, Ruczinski Ingo, Levin Albert M, Williams L Keoki, Beaty Terri H, Mathias Rasika A, Barnes Kathleen C, O'Connor Timothy D

Abstract excerpt

To characterize the extent and impact of ancestry-related biases in precision genomic medicine, we use 642 whole-genome sequences from the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) project to evaluate typical filters and databases. We find significant correlations between estimated African ancestry proportions and the number of variants per individual in all variant...

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PMID: 27725664
DOI: 10.1038/ncomms12521
PMCID: PMC5062569

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