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Article

Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia.

Pharmacogenomics - 1 Mar 2018

Umerez Maitane, Garcia-Obregon Susana, Martin-Guerrero Idoia, Astigarraga Itziar, Gutierrez-Camino Angela, Garcia-Orad Africa

Abstract excerpt

Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present...

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PMID: 29469670
DOI: 10.2217/pgs-2017-0164

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