Article
The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia.
Pharmacogenetics and genomics - 1 Aug 2017
Gutierrez-Camino Angela, Oosterom Natanja, den Hoed Marissa A H, Lopez-Lopez Elixabet, Martin-Guerrero Idoia, Pluijm Saskia M F, Pieters Rob, de Jonge Robert, Tissing Wim J E, Heil Sandra G, García-Orad Africa, van den Heuvel-Eibrink Marry M
Abstract excerpt
Five-year survival rates of pediatric acute lymphoblastic leukemia (ALL) have reached 90% in the developed countries. However, toxicity because of methotrexate (MTX) occurs frequently. Variety in the occurrence of toxicity is partly determined by single nucleotide polymorphisms (SNPs) in coding regions. Recently, five SNPs in non-coding pre-microRNAs and microRNA processing (miRNA) genes were identified in...
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