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Article

Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.

International journal of environmental research and public health - 1 Mar 2023

Lozano-Tovar Susana, Rodríguez-Agudelo Yaneth, Dávila-Ortiz de Montellano David José, Pérez-Aldana Blanca Estela, Ortega-Vázquez Alberto, Monroy-Jaramillo Nancy

Abstract excerpt

Alzheimer's disease (AD) is characterized by the presence of neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD). BPSD have been associated with the APOE_ε4 allele, which is also the major genetic AD risk factor. Although the involvement of some circadian genes and orexin receptors in sleep and behavioral disorders has been studied in some psychiatric pathologies, including AD, there are...

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PMID: 36901420
DOI: 10.3390/ijerph20054412
PMCID: PMC10001852

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