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Article

PERIOD3, circadian phenotypes, and sleep homeostasis.

Sleep medicine reviews - 1 Jun 2010

Dijk Derk-Jan, Archer Simon N

Abstract excerpt

Circadian rhythmicity and sleep homeostasis contribute to sleep phenotypes and sleep-wake disorders, some of the genetic determinants of which are emerging. Approximately 10% of the population are homozygous for the 5-repeat allele (PER3(5/5)) of a variable number tandem repeat polymorphism in the clock gene PERIOD3 (PER3). We review recent data on the effects of this polymorphism on sleep-wake regulation....

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Source

Identifiers

PMID: 19716732
DOI: 10.1016/j.smrv.2009.07.002

Genes

PER3

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Related research

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PERIOD3, circadian phenotypes, and sleep homeostasis.PMID 19716732Read ↗

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Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype.Semantic proximity Read ↗

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