Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).

doi:10.2174/1567205013666160603005630

Article

Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).

Current Alzheimer research - 1 Jan 2016

Pereira Patricia Araújo, Alvim-Soares António, Bicalho Maria Aparecida Camargos, Moraes Edgar Nunes de, Malloy-Diniz Leandro, Paula Jonas Jardim de, Romano-Silva Marco Aurélio, Miranda Debora Marques

Abstract excerpt

OBJECTIVES: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer's disease (AD) and/or late-onset depression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effects on AD and LOD pathology. DESIGN AND SUBJECTS: An exploratory...

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Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).

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