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Does RAS Status Increase the Prevalence of Positive Resection Margin in Colorectal Liver Metastasis? A Systematic Review and Meta-Analysis.

The American surgeon - 1 Dec 2023

Brandão Gabriela Rangel, Trindade Bruna Oliveira, Flores Luís Henrique Fernandes, Motter Sarah Bueno, Alves Cassio Bona, Remonti Tiago Auatt Paes, Lucchese Angélica Maria, Junior Antonio Dal Pizzol, Kalil Antonio Nocchi

Abstract excerpt

BACKGROUND: Colorectal liver metastasis has a high incidence, and RAS oncogene mutation status carries significant prognostic information. We aimed to assess whether RAS-mutated patients present more or less frequently with positive margins in their hepatic metastasectomy. METHODS: We performed a systematic review and meta-analysis of studies from PubMed, Embase, and Lilacs databases. We analyzed liver metastatic...

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PMID: 36896840
DOI: 10.1177/00031348231156763

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