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Article

Most synonymous allelic variants in HIV tat are not silent.

Genomics - 1 May 2023

Giacoletto Christopher J, Benjamin Ronald, Deng Hong-Wen, Rotter Jerome I, Schiller Martin R

Abstract excerpt

The genetic code has degenerate codons that produce no change in the translated protein sequence and are generally thought to be silent. However, some synonymous variants are clearly not silent. Herein, we questioned the frequency of non-silent synonymous variants. We tested how random synonymous variants in the HIV Tat transcription factor effect transcription of an LTR-GFP reporter. Our model system has the...

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Identifiers

PMID: 36893872
DOI: 10.1016/j.ygeno.2023.110603
PMCID: PMC10257815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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